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Acetoacetyl-CoA hydrolase

From Wikipedia, the free encyclopedia
acetoacetyl-CoA hydrolase
Identifiers
EC no.3.1.2.11
CAS no.37288-10-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

The enzyme acetoacetyl-CoA hydrolase (EC 3.1.2.11) catalyzes the reaction

acetoacetyl-CoA + H2O CoA + acetoacetate

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is acetoacetyl-CoA hydrolase. Other names in common use include acetoacetyl coenzyme A hydrolase, acetoacetyl CoA deacylase, and acetoacetyl coenzyme A deacylase. This enzyme participates in butanoate metabolism.

References

[edit]
  • Aragon JJ, Lowenstein JM (1983). "A survey of enzymes which generate or use acetoacetyl thioesters in rat liver". J. Biol. Chem. 258 (8): 4725–33. PMID 6131897.
  • Drummond GI, Stern JR (1960). "Enzymes of ketone body metabolism. II. Properties of an acetoacetate-synthesizing enzyme prepared from ox liver". J. Biol. Chem. 235: 318–25. PMID 13818236.